Genetically-encoded photosensitizer KillerOrange

- Blue and green light-induced production of reactive oxygen species
- Direct expression in cells, easy targeting to various subcellular compartments
- No exogenous chemical compounds required for chromophore maturation
- Not toxic before activation by blue or green light irradiation
- Recommended for selective light-induced protein inactivation and cell killing

Recommended antibodies, filter sets, and activating parameters

KillerOrange can be recognized using Anti-KillerRed antibody (Cat.# AB961) available from Evrogen.

KillerOrange phototoxicity can be induced by blue or green light irradiation (450-540 nm) and depends on light intensity, irradiation time and KillerOrange concentration and localization. LEDs light is strongly recommended; laser-light irradiation in confocal mode is much less efficient.